Pengaruh pemberian ekstrak meniran merah (Phyllanthus urinaria) terhadap penekanan jumlah limfosit pada organ timus mencit balb/C yang diinfeksi bakteri Salmonella thypi

Abstract

Ifandari, Suranto, Wuryaningsih YNS. 2012. Effect of Phyllanthus urinary extract on the suppression of lymphocytes in the thymus organs of mice BALB / C infected by Salmonella thypi bacteria. Bioteknologi 9: 1-6. Phyllanthus urinaria is one of species in genus Phyllanthus, which has variety of morphologycal characteristics and ussually used as traditional herb medicines. Now days, this plant has been intensivelly treated for laboratory experiment especially for diuretic, hipoglicemic, anti hepatitis B and anti cancer. The aims of this research were to investigat effect P.urinaria tretments on the total number of lymphocyte in thymus organs of mice Balb/C infected by Salmonella thypi; and to study the variety dosage effect of P. urinaria extracts to descrease lymphocyte cells. The study designed with post test only control group to 48 Balb/C mice. The experiment was 8 groups consist of negative control, positive control, treatments with variety dosage 3x0,065 mg/day, 3x0,130 mg/day and 3x0,260 mg/day for P.urinaria and P.niruri. The experiment was doing in 10 days with orally treatments, and Salmonella injected in mice at 4th day. At 11th day, mice were killed and the lymphocyte was isolated from thymus. Lymphocyte were counted. The results showed that P.urinaria treatments has descrease the total number of mice Balb/C lymphocyte on spleen to normal condition. The variety dosage of P.urinaria did not effect to descrease lymphocyte cell.