Ethnomedicine study of medicinal plants as malaria treatments in Moi Tribe, Southwest Papua, Indonesia

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ANISA TRI HUTAMI
WIWIED EKASARI
MARCELLINO RUDYANTO

Abstract

Abstract. Hutami AT, Ekasari W, Rudyanto M. 2025. Ethnomedicine study of medicinal plants as malaria treatments in Moi Tribe, Southwest Papua, Indonesia. Biodiversitas 26: 1124-1134. Moi Tribe is the indigenous tribe in Sorong District and Raja Ampat of the Southwest Papua Province, Indonesia, that still holds onto their traditional value, including maintaining their health. Living in the eastern part of Indonesia, where malaria is still prevalent, the Moi Tribe still use the traditional method to treat their illness using medicinal herbs according to the knowledge that has been passed down from their ancestor. Ethnomedicine is a study of the perception and conception of a local tribe in order to understand health, or a study to investigate the traditional medical system of a tribal community. The purpose of this study was to gain information on the use of natural products by the Moi Tribe community in Kampung Malaumkarta, Sorong District to treat malaria. The qualitative research method was employed, with in-depth interviews, purposive, and snowball sampling. The inclusion and exclusion criteria qualified 30 people as informants. The study's results indicate that, depending on the route of administration, 10 single concoctions are administered orally, while two plants are administered topically. Based on the number of citations, the most widely used traditional antimalaria plants are the stems of tali kuning (Arcangelisia flava) with 0.96 RFC (Relative Frequency of Citation) index, papaya leaf (Carica papaya) with 0.7 RFC, and leaf of Orthosiphon aristatus with 0.26 RFC. The most common mode of preparation of the herbal medicines is to boil them in two glasses of water, strain them, and drink the decoction. They usually consume a glass of the concoction twice a day until the condition improves, which typically takes two days. The topical treatments include the use of itchy leaves (Laportea decumana) that are rubbed onto the body part that feels sore, leaf of Premna serratifolia is rubbed on the forehead to relieve headaches. Most of the plants that are used by the tribe have been shown to have various pharmacological effects.

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References
Abdillah S, Tambunan RM, Farida Y, Sandhiutami NMD, Dewi RM. 2015. Phytochemical screening and antimalarial activity of some plants traditionally used in Indonesia. Asian Pac J Trop Dis 5 (6): 454-457. DOI: 10.1016/S2222-1808(15)60814-3.
Akinniyi G, Lee J, Kim H, Lee J-G, Yang I. 2022. A medicinal halophyte Ipomoea pes-caprae (Linn.) R. Br.: A review of its botany, traditional uses, phytochemistry, and bioactivity. Mar Drugs 20 (5): 329. DOI: 10.3390/md20050329.
Alshehade SA, Al Zarzour RH, Mathai M, Giribabu N, Seyedan A, Kaur G, Al-Suede FSR, Majid AMSA, Murugaiyah V, Almoustafa H, Alshawsh MA. 2023. Orthosiphon aristatus (Blume) Miq alleviates non-alcoholic fatty liver disease via antioxidant activities in C57BL/6 obese mice and palmitic-oleic acid-induced steatosis in HepG2 cells. Pharmaceuticals 16 (1): 109. DOI: 10.3390/ph16010109.
Anna Z. 2016. Kajian Valuasi Ekonomi Lanskap Masyarakat Adat Moi Kelim Di Kampung Malaumkarta, Papua Barat. I. Aliansi Masyarakat Adat Nusantara (AMAN), Jakarta. [Indonesian]
Bhagawan WS, Ekasari W, Agil M. 2024. Ethnobotanical survey of herbal steam baths among the Tenggerese community in Bromo Tengger Semeru National Park, Indonesia. IOP Conf Ser: Earth Environ Sci 1352: 012103. DOI: 10.1088/1755-1315/1352/1/012103.
BPS Kabupaten Sorong. 2023. Kabupaten Sorong dalam Angka. BPS Kabupaten Sorong. BPS Kabupaten Sorong, Sorong. https:// sorongkab.bps.go.id/id/publication/2023/02/28/80ed380cfef9b6d2b99acd26/kabupaten-sorong-dalam-angka-2023.html. [Indonesian]
Budiarti M, Maruzy A, Mujahid R, Sari AN, Jokopriyambodo W, Widayat T, Wahyono S. 2020. The use of antimalarial plants as traditional treatment in Papua Island, Indonesia. Heliyon 6 (12): e05562. DOI: 10.1016/j.heliyon.2020.e05562.
Chai T-T, Wong F-C, Abd Manan F, Fei OK, Ismail NIM. 2014. Orthosiphon aristatus?: A review of traditional uses, phytochemical profile, and pharmacological properties. In: Gupta VK (eds). Traditional and Folk Herbal Medicine: Recent Researches. Daya Publishing House, New Delhi.
Chao W-W, Lin B-F. 2010. Isolation and identification of bioactive compounds in Andrigraphis paniculata (Chuanxinlian). Chin Med 5: 17. DOI: 10.1186/1749-8546-5-17.
Dagen M. 2020. History of malaria and its treatment. In: Patrick GL (eds). Antimalarial agents: Design and mechanism of action history of malaria and its treatment. Elsevier Ltd, Amsterdam, The Netherlands. DOI: 10.1016/B978-0-08-101210-9.00001-9.
Dwivedi MK, Mishra S, Sonter S, Singh PK. 2021. Diterpenoids as potential anti-malarial compounds from Andrographis paniculata. Beni-Suef Univ J Basic Appl Sci 10: 7. DOI: 10.1186/s43088-021-00098-8.
Hapsari Y, Simanjuntak P, Kusharyoto W, Hudiyono S. 2019. Chemical constituent and antimalarial activity based on inhibition of heme polymerization from water extract of yellow root (Arcangelisia flava L. Merr). Chimica et Natura Acta 7: 102. DOI: 10.24198/cna.v7.n3.26264.
Keawpradub N, Dej-Adisai S, Yuenyongsawad S. 2005. Antioxidant and cytotoxic activities of Thai medicinal plants named Khaminkhruea. Songklanakarin J Sci Technol 27 (Suppl 2): 456-466.
Kubo M, Yatsuzuka W, Matsushima S, Harada K, Inoue Y, Miyamoto H, Matsumoto M, Fukuyama Y. 2016. Antimalarial phenanthroindolizine alkaloids from Ficus septica. Chem Pharm Bull 64 (7): 957-960. DOI: 10.1248/cpb.c16-00181.
La Basy L, Hertiani T, Murwanti R, Damayanti E. 2024. Investigation of Cox-2 inhibition of Laportea decumana (Roxb). Wedd extract to support its analgesic potential. J Ethnopharmacol 318 (Pt A): 116857. DOI: 10.1016/j.jep.2023.116857.
La Basy L, Santosa D, Murwanti R, Hertiani T. 2022. Uncover itchy leaves ethnomedicine usage: A preliminary study on characterization and bioactivity of Laportea spp. Pharmacogn J 14 (4): 286-295. DOI: 10.5530/pj.2022.14.98.
Luceñara DCP, Ombat LA, Won MEQ, Rosal JJ. 2022. Antimitotic and antiproliferative action of Ficus septica Burm. F. stem bark ethanolic extract. Cytologia 87 (4): 363-367. DOI: 10.1508/cytologia.87.363.
Mali PY. 2016. Pharmacological potentials of Premna integrifolia L. Anc Sci Life 35 (3): 132-142. DOI: 10.4103/0257-7941.179864.
Manigauha A, Kharya MD, Ganesh N. 2015. In vivo antitumor potential of Ipomoea pes-caprae on melanoma cancer. Pharmacogn Mag 11 (42): 426-433. DOI: 10.4103/0973-1296.153099.
Maryani, Marsoedi, Nursyam H, Maftuch. 2013. The phytochemistry and the anti-bacterial activity of yellow root (Arcangelisia flava Merr.) against Aeromonas hydrophila. J Biol Life Sci 4 (2): 180-190. DOI: 10.5296/jbls.v4i2.3683.
Ministry of Health of the Republic of Indonesia. 2022. Laporan Tahunan 2022 Malaria. Kemenkes RI: 1-51. https://www.bca.co.id/-/media/ Feature/Report/File/S8/Laporan-Tahunan/20230216-bca-ar-2022-indonesia.pdf. [Indonesian]
Mishra K, Dash AP, Swain BK, Dey N. 2009. Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin. Malaria J 8: 26. DOI: 10.1186/1475-2875-8-26.
Mutiah R, Kirana FO, Annisa R, Rahmawati A, Sandra F. 2020. Extract of yellow root (Arcangelisia flava (L.) Merr.) from several regions in Kalimantan: Alkaloid content and cytotoxicity towards WiDr colorectal cancer cells. Indones J Cancer Chemoprevention 11 (2): 84-89. DOI: 10.14499/indonesianjcanchemoprev11iss2pp84-89.
Nugroho Y, Soendjoto MA, Suyanto, Matatula J, Alam S, Wirabuana PYAP. 2022. Traditional medicinal plants and their utilization by local communities around Lambung Mangkurat Education Forests, South Kalimantan, Indonesia. Biodiversitas 23 (1): 306-314. DOI: 10.13057/biodiv/d230137.
Pandey SK, Anand U, Siddiqui WA, Tripathi R. 2023. Drug development strategies for malaria: With the hope for new antimalarial drug discovery-An update. Adv Med 2023: 5060665. DOI: 10.1155/2023/5060665.
Pazzini IAE, de Melo AM, Ribani RH. 2021. Bioactive potential, health benefits and application trends of Syzygium malaccense (Malay apple): A bibliometric review. Trends Food Sci Technol 116: 1155-1169. DOI: 10.1016/j.tifs.2021.09.012.
Pothula VVS, Kanikaram S. 2015. In vitro antiplasmodial efficacy of mangrove plant, Ipomoea pes-caprae against Plasmodium falciparum (3D7 Strain). Asian Pac J Trop Di 5 (12): 947-956. DOI: 10.1016/S2222-1808(15)60963-X.
Pratama RR, Sholikhah I, Sukardiman, Sahu RK, Widyowati R. 2023. Phytochemical compounds identification from 70% ethanol extract of Arcangelesia flava (L.) Merr stems using LC-MS/MS and in-silico molecular docking approach as inhibitor Interleukin-1?. Pharmacogn J 15 (4): 528-534. DOI: 10.5530/pj.2023.15.114.
Ragasa CY, Macuha MR, De Los Reyes MM, Mandia EH, Van Altena IA. 2016. Chemical constituents of Ficus septica Burm. F. Intl J Pharm Clin Res 8 (11): 1464-1469.
Reddy MS, Kuber BR, Visvavidyalayam PM. 2019. Antiplasmodial activity of Alstonia scholaris. Intl J Pharm Biol Sci 9 (2): 656-663.
Sambo AS, Sutiono W, Fajar MN. 2024. Perencanaan jalur evakuasi bencana tsunami menggunakan metode Sistem Informasi Geografis (SIG) di Kampung Malaumkarta Distrik Makbon Kabupaten Sorong. Jurnal Ilmiah Teknik Sipil 3: 81-95. DOI: 10.33506/jimats.v3i02.3865. [Indonesian]
Santhose BI, Adhikary P, Bharathi SS, Kayali A, Sathishkumar K, Almutairi BO, Gaurav GK, Thanigaivei S. 2023. In vitro screening and characterization of phytochemical products from Alstonia scholaris (Linn) and its bioactive potential for sustainable application. Biomass Convers Bioref 2023: 1. DOI: 10.1007/s13399-023-05151-3.
Seyfe S, Toma A, Esaiyas A, Debela E, Fikru A, Eyado A. 2017. Phytochemical screening and in vivo antimalarial activities of crude extracts of Lantana trifolia root and Premna oligotricha leaves in Plasmodium berghei infected mice. J Med Plants Res 11 (47): 763-769. DOI: 10.5897/JMPR2017.6519.
Sharma A, Bachheti A, Sharma P, Bachheti RK, Husen A. 2020. Phytochemistry, pharmacological activities, nanoparticle fabrication, commercial products and waste utilization of Carica papaya L.: A comprehensive review. Curr Res Biotechnol 2: 145-160. DOI: 10.1016/j.crbiot.2020.11.001.
Simaremare ES, Gunawan E, Yarangga I, Satya MD, Yabansabra YR. 2020. Antibacterial and toxicity activities itchy leaves (Laportea decumana Roxb. Wedd) extract. J Phys: Conf Ser 1503: 012041. DOI: 10.1088/1742-6596/1503/1/012041.
Singh YD, Panda MK, Satapathy KB. 2020. Ethnomedicine for drug discovery. In: Patra J, Shukla A, Das G (eds). Advances in Pharmaceutical Biotechnology. Springer, Singapore. DOI: 10.1007/978-981-15-2195-9.
Soib HH, Ismail HF, Husin F, Bakar MHA, Yaakob H, Sarmidi MR. 2020. Molecules bioassay-guided di ff erent extraction techniques of. Molecules 25 (3): 517. DOI: 10.3390/molecules25030517.
Soni R, Shankar G, Mukhopadhyay P, Gupta V. 2022. A concise review on Artemisia annua L.: A major source of diverse medicinal compounds. Ind Crops Prod 184: 115072. DOI: 10.1016/j.indcrop.2022.115072.
Suaib HH. 2017. Nilai-Nilai Kearifan Lokal dan Modal Sosial dalam Pemberdayaan Masyarakat Suku Moi. An1mage, Tangerang. [Indonesian]
Susanti RD. 2023. Kearifan Kesehatan Lokal: Indigenous Medical Knowledge and Practice for Integrated Nursing of the Elderly with Cardiovascular Disease in Sumedang, West Java: Towards Transcultural Nursing in Indonesia Chapter II Theoretical Orientation. In Leiden Ethnosystems and Development Programme Studies, Leiden University.
Sudirga SK, Suprapta DN, Sudana IM, Wirya IGNAS. 2014. Antifungal activity of leaf extract of Ficus septica against Colletotrichum acutatum the cause of anthracnose disease on chili pepper. J Biol Agric Healthcare 4 (28): 47-52.
Tadesse SA, Wubneh ZB. 2017. Antimalarial activity of Syzygium guineense during early and established Plasmodium infection in rodent models. BMC Complement Altern Med 17 (1): 21. DOI: 10.1186/s12906-016-1538-6.
Taek MM, Bambang Prajogo EW, Agil M. 2018. Ethnomedicinal plants used for the treatment of malaria in Malaka, West Timor. J Young Pharm 10 (2): 187-192. DOI: 10.5530/jyp.2018.10.42.
Taek MM, Banilodu L, Neonbasu G, Watu YV, Bambang Prajogo EW, Agil M. 2019. Ethnomedicine of Tetun Ethnic people in West Timor Indonesia: Philosophy and practice in the treatment of malaria. Integr Med Res 8 (3): 139-144. DOI: 10.1016/j.imr.2019.05.005.
Tardío J, Pardo-De-Santayana M. 2008. Cultural importance indices: A comparative analysis based on the useful wild plants of Southern Cantabria (Northern Spain). Econ Bot 62: 24-39. DOI: 10.1007/s12231-007-9004-5.
Teng W-C, Chan W, Suwanarusk R, Ong A, Ho H-K, Russell B, Rénia L, Koh H-L. 2019. In vitro antimalarial evaluations and cytotoxicity investigations of Carica papaya leaves and carpaine. Nat Prod Commun 14 (1): 33-36. DOI: 10.1177/1934578X1901400110.
Uddin ABMN, Hossain F, Reza ASMA, Nasrin MS, Alam AHMK. 2022. Traditional uses, pharmacological activities, and phytochemical constituents of the genus Syzygium: A review. Food Sci Nutr 10 (6): 1789-1819. DOI: 10.1002/fsn3.2797.
Ugbogu EA, Dike ED, Uche ME, Etumnu LR, Okoro BC, Ugbogu OC, Adurosakin OE, Chinma CE, Ohaeri E, Iweala EJ. 2023. Ethnomedicinal uses, nutritional composition, phytochemistry and potential health benefits of Carica papaya. Pharm Res Modern Chin Med 7: 100266. DOI: 10.1016/j.prmcm.2023.100266.
Vun-Sang S, Iqbal M. 2023. Phytochemical analysis and antioxidant activity of aqueous extract of Ficus septica leaves from Sabah, Malaysia. Borneo J Resour Sci Technol 13 (2): 67-78. DOI: 10.33736/bjrst.5591.2023.
WHO [World Health Organization]. 2023. World Malaria Report 2023 -- Spread View. https://www.who.int/about/licensing.
Yuliana H. 2018. Model partisipasi Masyarakat Moi dalam pelaksanaan pendidikan adat Kambik (Studi kasus tentang kelangsungan pendidikan Kambik di Suku Moi Kampung Maladofok Kabupaten Sorong). Jurnal Noken: Ilmu-Ilmu Sosial 4: 87-106. DOI: 10.33506/jn.v4i1.60. [Indonesian]
Zainul R, Verawati R, Alam G, Nisyak K, Sari TK, Ghifari MA, Ruga R, Azhari P, Romadhon, Barroroh H, Mandeli RS, Purnamasari D, Kharisma VD, Jakhmola V, Rebezov M, Ansori ANM. 2023. Interaction of cynaroside from Orthosiphon aristatus plant extract on TNF alpha as a stimulant in malaria and asthma. Pharmacogn J 15 (4): 581-586. DOI: 10.5530/pj.2023.15.123.
Zhang R, Lv J, Yu J, Xiong H, Chen P, Cao H, Martin JJJ. 2022. Antioxidant analysis of different parts of several cultivars of papaya (Carica papaya L.). Intl J Fruit Sci 22 (1): 438-452. DOI: 10.1080/15538362.2022.2047138.