Short Communication: Relationship between interferon-tau level (IFN- ?) and embryo mortality incident in Aceh cattle
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Abstract. Melia J, Siregar TN, Alfahmi L, Husnurrizal, Saumar H, Mukhtar, Meutia N, Panjaitan B, Armansyah T. 2020. Short Communication: Relationship between interferon-tau level (IFN- ?) and embryo mortality incident in Aceh cattle. Biodiversitas 21: 5758-5762. The purpose of this research is to determine the relationship between interferon-tau level (IFN-?) and the incidence of embryo mortality in Aceh cattle from the Province of Aceh, Indonesia. Data were obtained from four Aceh cattle, aged 3-5 years and body weight of 150-250 kg. The cattle were clinically healthy, with at least two regular reproduction cycles, and a pregnant status after estrous synchronization and artificial insemination. This process was carried out on a 10-day interval using the intramuscular administration of prostaglandin F2 alpha (PGF2?) hormone, at a dose of 25 mg, with double injection pattern. The blood samples were collected from the jugular vein on day 14 to 18 post-insemination for the assessment of IFN-? concentration, which was measured using the enzyme linked-immunoassay (ELISA) method and the bovine interferon ELISA kit (Cusabio Technology LLC AII, USA). In addition, the transrectal ultrasonography method was used to test the pregnancy and embryo mortality of the cattle on the 25th day. The examination was repeated every 10 days until day 55. The IFN-? concentrations of pregnant cows against those with embryo mortality on the 14th, 15th, 16th, 17th, and 18th day, were 12.066±8.222 vs 17.853±11.126, 12.983±3.491 vs 20.503±3.858, 12.193±4.535 vs 16.458±8.065, 10.143±5.370 vs 17.604±1.888, and 12.767±7.753 vs 15.096±6.955 pg/mL, respectively. Therefore, the embryo mortality in Aceh cattle is not related to IFN-?.
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References
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Yaginuma H, Funeshima N, Tanikawa N, Miyamura M, Tsuchiya H, Noguchi T, Iwata H, Kuwayama T, Shirasuna K, Hamano S. 2019. Improvement of fertility in repeat breeder dairy cattle by embryo transfer following artificial insemination: Possibility of interferon tau replenishment effect. J Reprod Dev 65 (3): 223-229.
Zhu Z, Li B, Wu Y, Wang X, Deng G. 2017. Interferon-t increases BoLA-I for implantation during early pregnancy in dairy cows. Oncotarget 8 (56): 95095-9107.
Amrozi, Setiawan B. 2011. Sinkronisasi estrus dan pengamatan ultrasonografi pemeriksaan kebuntingan dini pada domba garut (Ovis aries) sebagai standar penentuan umur kebuntingan. J Kedokt Hewan, 5 (2): 73-77.
Antoniazzi AQ, Latimer AM, Romero JJ, Niswender GD, Bazer FW, Nett TM, Hansen TR. 2012. Detection of interferon-tau in uterine vein blood using a highly sensitive and specific radioimmunoassay. Biol Reprod 87 (1): 183-188.
Arosh JA, Banu SK and McCracken JA, 2016. Novel concepts on the role of prostaglandins on luteal maintenance and maternal recognition and establishment of pregnancy in ruminants. J Dairy Sci 99 (7): 5926-5940.
Balhara AK, Mohanty AK, Gupta M, Singh I. 2013. Early pregnancy diagnosis in bovines: Current status and future directions. Sci World J 2013: 1-10.
Basavaraja R, Madusanka ST, Drum JN, Shrestha K, Farberov S, Wiltbank MC, Sartori R, Meidan R. 2019. Interferon-tau exerts direct prosurvival and antiapoptotic actions in luteinized bovine granulosa cells. Scientific Reports 9: 1-11.
Bazer FW, Spencer TE, Johnson GA, Burghardt RC, Wu G. 2009. Comparative aspects of implantation. Reproduction 138 (2): 195-209.
Bazer FW, Wu G, Spencer TE, Johnson GA, Burghardt RC and Bayless K, 2010. Novel pathways for implantation and establishment and maintenance of pregnancy in mamals. Mol Hum Reprod 16 (3): 135-152.
Chaudary AK, Purohit GN. 2012. Ultrasonographic detection of early pregnancy loss in dairy cows. J Anim Sci Adv 2 (8): 706-710.
Dorniak P, Spencer TE, 2013. Biological roles of progesterone, prostaglandins, and interferon tau in endometrial function and conceptus elongation in ruminants. Anim Reprod 10 (3): 239-251.
Efendi M, Siregar TN, Hamdan H, Dasrul D, Thasmi CN, Daud R, Sayuti A, Panjaitan B. 2015. Angka kebuntingan sapi lokal setelah diinduksi dengan protokol ovsynch. J Med Vet 9 (2): 159-162.
Farin CE, Imakawa K, Hansen TR, McDonell JJ, Murphy CN, Farin PW, Roberts RM. 1980. Expression of trophoblastic interferon genes in sheep and cattle. Biol Reprod 43 (2): 210-218.
Guo R, Chen F, Mei C, Dai Z, Yan L, Shi Z. 2020. Conception rate and reproductive hormone secretion in Holstein cows immunized against inhibin and subjected to the ovsynch protocol. Animals 10 (2): 1-10.
Hansen TR, Sinedino LDP, Spencer TE. 2017. Paracrine and endocrine actions of interferon tau (IFNT). Reproduction 154 (5): 45-59.
Humblot P. 2001. Use of pregnancy specific proteins and progesterone assays to monitor pregnancy and determine the timing, frequencies and sources of embryonic mortality in ruminants. Theriogenology 56 (9): 1417-1433.
Imakawa K, Bai R, Nakamura K, Kusama K. 2017. Thirty years of interferon-tau research: Past, present and future perspective. A review article. Anim Sci J 88 (7): 927-936.
Lucy M, Poock S. 2012. Pregnancy determination by palpation and beyond. Proceedings Applied Reproductive Strategies in Beef Cattle December 3 - 4, Sioux Falls, SD
Martal J, Charlier M, Charpigny G, Camous S, Chene N, Reinaud P, Sade S, Guillomot M. 1987. Interference of trophoblastin in ruminant embryonic mortality: A review. Livest Prod Sci 17: 193-210.
Matsuyama S, Kojima T, Kato S, Kimura K. 2012. Relationship between quantity of IFNT estimated by IFN-stimulated gene expression in peripheral blood mononuclear cells and bovine embryonic mortality after AI or ET. Reprod Biol Endocrinol 10(21): 1-10.
Mishra SR and Sarkar M. 2018. Interferon stimulated genes (ISGs): Novel pregnancy specific biomarker in buffaloes (Bubalus bubalis). J Immunol Sci 2 (2): 48-51.
Noakes D, Parkinson T, England G, Arthur G. 2001. Arthur's Veterinary Reproduction and Obstetrics. 8th ed. Saunders Ltd., USA.
Prihatno SA, Kusumawati A, Karja NWK, Sumiarto B, 2013. Prevalensi dan faktor resiko kawin berulang pada sapi perah pada tingkat peternak. J Vet 14 (4): 452-461.
Rafika I. 2017. Isolasi dan Identifikasi Bakteri Gram Negatif pada Uterus Sapi Aceh yang Mengalami Repeat Breeding. [Thesis]. Syiah Kuala University, Banda Aceh . [Indonesia].
Raheem KA. 2017. An insight into maternal recognition of pregnancy in mammalian species. J Saudi Soc Agricult Sci 16 (1): 1-6.
Roberts RM. 2007. Interferon-tau, a type 1 interferon involved in maternal recognition of pregnancy. Cytokine Growth Factor Rev 18 (5-6): 403-408.
Sayuti A, Melia J, Marpaung IK, Siregar TN, Syafruddin, Amiruddin, Panjaitan B. 2016. Diagnosis kebuntingan dini pada kambing kacang (Capra sp.) menggunakan ultrasonografi transkutaneus. J Kedok Hewan 10 (1): 63-67.
Senger PL. 2005. Pathways to Pregnancy and Parturition. Washington State University Research & Technology Park. 2nd revised edition. Current Conception Inc., Washington.
Serrano-Pérez B, Rizos D, López-Helguera I, Molina E, Garcia-Ispierto I, López-Gatius F. 2019. Progesterone supplementation during the preimplantation period influences interferon-stimulated gene expression in lactating dairy cows. Ann Anim Sci 19 (3): 713-724.
Sheikh AA, Hooda OK, Kalyan A, Kamboj A, Mohammed S, Alhussein M, Reddi S, Shimray PG, Rautela A, Pandita S, Kapila S, De S, Dang AK. 2018. Interferon tau stimulated gene expression: A proxy to predict embryonic mortality in dairy cows. Theriogenology 120: 61-67.
Spencer TE, Bazer FW. 2015. Implantation and establishment of pregnancy in ruminants. Adv Anat Embryol Cell Biol 216: 105-135.
Spencer TE, Forde N, Dorniak P, Hansen TR, Romero JJ, Lonergan P. 2013. Conceptus-derived prostaglandins regulate gene expression in the endometrium prior to pregnancy recognition in ruminants. Reproduction 146 (4): 377-387.
Spencer TE, Ing NH, Ott TL, Mayes JS, Becker WC, Watson GH, Mirando MA, Brazer FW. 1995. Intrauterine injection of ovine interferon-tau alters oestrogen receptor and oxytocin receptor expression in the endometrium of cyclic ewes. J Mol Endocrinol 15 (2): 203-220.
Sudarmaji S, Malik A, Gunawan A. 2007. Pengaruh penyuntikan prostaglandin terhadap persentase birahi dan angka kebuntingan sapi bali dan Po di Kalimantan Selatan. https://www.neliti.com/publications/ 164346/pengaruh-penyuntikan-prostaglandin-terhadap-persentase-birahi-dan-angka-kebuntin.
Wiltbank MC, Baez GM, Garcia-Guerra A, Toledo MZ, Monteiro M, Melo PL, Ochoa JC, Santos JE, Sartori R. 2016. Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows. Theriogenology 86 (1): 239-253.
Yaginuma H, Funeshima N, Tanikawa N, Miyamura M, Tsuchiya H, Noguchi T, Iwata H, Kuwayama T, Shirasuna K, Hamano S. 2019. Improvement of fertility in repeat breeder dairy cattle by embryo transfer following artificial insemination: Possibility of interferon tau replenishment effect. J Reprod Dev 65 (3): 223-229.
Zhu Z, Li B, Wu Y, Wang X, Deng G. 2017. Interferon-t increases BoLA-I for implantation during early pregnancy in dairy cows. Oncotarget 8 (56): 95095-9107.
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