Blood glucose and total cholesterol content of hyperglycemic white male rat (Rattus norvegicus L.) after orally intakes of methanol meniran (Phyllanthus niruri L.) root extract

Abstract

Abstract. The aims of this research were to study the effect of methanol meniran (Phyllanthus niruri L.) root extract on blood glucose and total cholesterol content. The concentration level has a significant effect on alloxan treatment. Meniran root contains ellagic acid as an antioxidant which provides the hypoglycemic capability to reduce diabetic blood glucose. This research was done using a completely randomized design (CRD) including eight treatments as follow: negative control (CMC 1%, 2 mL/200 g BW), positive control (glibenclamide 0,126 mg/200 g bw), normal control, meniran root extract in various concentration (2; 4; 6; 8; 10 mg/200 g bw). Data were elucidated until 15 days of treatment and analyzed using ANOVA followed by DMRT at a 5% confidence level. The result indicated that meniran root extract has a significant effect on reducing blood glucose. However, it does not appear to have the same result as total cholesterol content. At various concentrations of meniran root extract, the total cholesterol of rats remains stable. The optimum concentration to provide hypoglycemic activity raised at 10 mg/200 b bw dose.