Effects of turmeric extract (Curcuma domestica Val.) on the increase of SGOT and SGPT level in the mice (Rattus norvegicus) due to the acetaminophen administration

Abstract

Abstract. Turmeric (Curcuma domestica Val.) contains a peculiar curcumin substance with medical merit. The results of various types of study with curcumin show that it could restore damaged liver cells; therefore, it is predicted that the turmeric extract also bears the same ability. This study aims at finding out whether there is an effect of the turmeric extract on the increase of SGOT and SGPT levels in the mice due to the acetaminophen administration. This is an experimental study with a post-test-only controlled group design. The research used were 20 male mice (Rattus norvegicus), Strain Wistar, aged + 2 months old, weighed 150 grams. They were divided into 4 groups, consisting of 4 mice. Group 1 was the control group. Group 2 was exposed to past administration of acetaminophen with the toxic dosage of 1.35 grams over each kilogram of body weight. Groups 3 and 4 were each given turmeric extract with the dosage of 5 milligrams and 10 milligrams over each kilogram of body weight, respectively; after two hours, they were subject to past acetaminophen administration with the dosage of 1.35 grams over each kilogram of body weight. Data gathering was then conducted following 48 hours of the latest treatment by taking the blood samples of the mice through their sinus orbitalis. The blood samples from the 4 groups were then examined for their SGOT and SGPT levels with a kinetic method. The data were analyzed using ANOVA followed by Post Hoc Test using Tukey test completed with homogenous subsets. The results show a significant effect of the turmeric extract on increasing the SGOT and SGPT levels in the mice due to the acetaminophen administration.