Bioactive compound that inhabit quorum sensing system in gram negative bacteria

Abstract

Abstract. Bacteria communicate using chemical signaling molecules as words. They release, detect, and respond to the accumulation of these molecules, which are called autoinducers. Detection of autoinducers allows bacteria to distinguish between low and high cell population density, and to control gene expression in response to changes in the cell number. This process is termed quorum-sensing. Many bacterial behaviors are regulated by quorum-sensing, including virulence factors on Gram-negative bacteria. Quorum-sensing is a novel target for antimicrobial therapies. Many eukaryotes including plants, fungus, and animals produce molecules that can interfere with bacteria communication, such as halogen furanone from alga Delisea pulchra, N- (heptylsulfanylacetyl)-L-homoserine-lactone from Allium sativum, and flustramine from bryozoan Flustra foliacea.