Effect of garlic extract (Allium sativum) on hepatic microanatomy structure and serum glutamate-pyruvate transaminase levels in rats after oral treatment of CCl4

Abstract

Abstract. Garlic (Allium sativum L.) has various pharmacological activities, such as antidiabetic, antihypertensive, anti-cholesterol, anti-atherosclerosis, thrombocyte anti-aggregation, and initiating fibrinolysis antiviral and antimicrobial, anticancer, and antioxidant. The objectives of this research were to determine the effect of garlic extract (Allium sativum L.) on the microanatomy structure of the liver and the serum glutamate-pyruvate transaminase (SGPT) levels in rats (Rattus norvegicus L.) after the oral treatment of carbon tetrachloride (CCl₄). The study was conducted using 25 Wistar strain rats aged 2-3 months with bodyweight 200-250 grams divided into five groups; each group consisted of 5 rats as replicates kept under the same conditions and treated for 28 days. The results showed that garlic extract treatment improved the microanatomy structure of damaged liver cells in rats after oral carbon tetrachloride (CCl₄). The damage was in the fatty liver, pyknotic, karyorrhexis, karyolysis, and central vein dilatation. The garlic extract treatment also reduced the serum pyruvate-transaminase glutamate (SGPT) levels in rats after the oral treatment of carbon tetrachloride (CCl₄).