Preparation of essential oil ointment of lime leaves (Citrus amblycarpa) and stability test on type-based used
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Abstract
Abstract. Nareswari N, Kuncoro A. 2016. Preparation of essential oil ointment of lime leaves (Citrus amblycarpa) and stability test on type-based used. Biofarmasi 14: 63-68. Citrus lime has volatile oil content in the leaves and the skin—essential oils from the leaves of citrus lime-containing ?-pinene, linalool, citronellal, and geraniol citronellol. The yield of essential oil of citrus lime leaves at 0,47% could inhibit the growth of bacteria S. aureus with KBM and the MIC values of 0,039% (v / v). This research is a design experiment that used Pre-Test/Post-Test Control Desain. The essential oil for skin medication must be made in practical and stable preparation. The ointment is a semi-solid preparation that is easy to apply and use as an external medicine. The use of essential oil of citrus lime leaf was made in ointment preparation with three varieties of basis: water-soluble basis, absorptive bases, and base hydrocarbon, for the ointment to be easily applied the skin. The physical stability test series, which consisted of the homogeneity, organoleptic, viscosity, adhesiveness, dispersiveness, and the acidity level (pH) of the ointment preparation, were tested for 8 weeks to investigate the most stable ointment basis out of the three formulae to make the ointment of the essential oil of citrus lime (Citrus amblycarpa (Hassk) Ochse). Next, the stability of the ointment preparations was investigated from the data, which contained the observation results from the first week to the eighth week. The data were analyzed statistically by using the Kolmogorov-Smirnov analysis technique. Finally, the data were analyzed using the one-way Analysis of Variance (ANOVA) to investigate the effect of the difference in the ointment's basis on the ointment preparations' stability. The research results indicate that all three types of base oils used in ointment citrus lime leaves have a good physical stability test based on viscosity, acidity level (pH), dispersiveness, and adhesiveness.