Antioxidant and alpha-glucosidase inhibitory activities of Euchresta horsfieldii
##plugins.themes.bootstrap3.article.main##
Abstract
Abstract. Prihantini AI, Krisnawati, Setyayudi A. 2019. Antioxidant and alpha-glucosidase inhibitory activities of Euchresta horsfieldii. Biofarmasi J Nat Prod Biochem 17: 65-68. Euchresta horsfieldii, known as pranajiwa, is a medicinal plant widely grown in Bali and West Nusa Tenggara, Indonesia. Its seeds or fruits are commonly used for body freshness and stamina. The present study aimed to investigate the biological activities of leaves, roots, stems, fruits, and seeds of E. horsfieldii. Antioxidants, alpha-glucosidase inhibitory activities, and total phenolic compounds were evaluated from methanolic extracts of all parts of E. horsfieldii. The result showed that leaf extract of E. horsfieldii exhibited the highest antioxidant activity with IC50 215.11±08.06 µg/mL. Meanwhile, the root extract had the highest alpha-glucosidase inhibitory activity and total phenolic compound with IC50 29.76±13.17 µg/mL and 763±0.01 mg GAE/100mg dry extract, respectively. In conclusion, the study suggested that E. horsfieldii is the potential as a natural source of antioxidant and alpha-glucosidase inhibitor agents.
##plugins.themes.bootstrap3.article.details##
Basma AA, Zakaria Z, Lactha YL, Sasidharan S. 2011. Antioxidant activity and phytochemical screening of the methanol extracts of Euphorbia hirta L. Asian Pac J Trop Med 5:386-390.
Chanda S and Dave R. 2009. In vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: an overview. Afr J Mic Res 3:981-996.
Cheng AYY and Josse RG. 2004. Intestinal absorption inhibitors for type 2 diabetes mellitus: prevention and treatment. Drug Discov Today: Ther Strateg1(2):201-206.
Dewi RT, Tachibana S, Darmawan A. Effect on a-glucosidase inhibition and antioxidant activities of butyrolactone derivatives from Aspergillus terreus MC75. 2014. Med Chem Res 23:454–460.
El-Haci IA, Bekkara FA, Mazari W, Gherib M. 2013. Phenolics content and antioxidant activity of some organic extracts of endemic medicinal plant Anabasis aretioides Coss. & Moq. from Algerian sahara. Pharmacogn J 5: 108–112.
Emami SA, Asili J, Mohagheghi Z, Hassanzadeh MK. 2007. Evid Based Complement Alternat Med 4(3):313-319. Doi: 10.1093/ecam/nem011. Antioxidant activity of leaves and fruits of Iranian Conifers.
Ghadyale V, Takalikar S, Haldavnekar V, and Arvindekar A. 2011. Effective control of postprandial glucose level through inhibition of intestinal alpha glucosidase by Cymbopogon martini (Roxb.). Evid Based Complement Alternat Med. Hindawi Publishing Corporation.
Gunawan IWG, Puspawati NM, Dewi NWRK, Parwata MOA. 2017. Effect of Euchresta horsfieldii Lesch Benn. leaf extract on increases enzyme activity of superoxide dismutase and glutathione peroxidase in rats with maximum physical activity. J Pharm Sci and Res 9(5):578-582.
Gurudeeban S, Satyavani K, Ramanathan T. 2012. Alpha glucosidase inhibitory effect and enzyme kinetics of coastal medicinal plants. Bangladesh J Pharmacol 7:186-191.
Ha H, Hwang I, Park JH, Lee HB. 2008. Role of reactive oxygen species in the pathogenesis of diabetic nephropathy. Diabetes Res and Clin Pract 825:542-545.
Heyne, K. 1987. Tumbuhan berguna Indonesia. Badan Litbang Kehutanan, Departemen Kehutanan Indonesia. Yayasan Sarana Wana Jaya, Jakarta.
Jayaprakasha GK, Singh RP, Sakariah KK. 2001. Antioxidant activity of grape seed (Vitis vinifera) extracts on peroxidation models in vitro. Food chemistry. 73:285–290.
Khalaf NA, Shakya AK, Al-Othman A, El-Agbar Z, Farah H. 2007. Antioxidant activity of some common plants. Turk J Biol 32:51–55.
Kim JH, Kim D, Kim J, Hwang JK. 2011. Euchresta horsfieldii Benn. Activates peroxisome proliferator-activated receptor ? and regulates expression of genes involved in fatty acid metabolism in human HepG2 cells. J Ethnopharmacol 133:244-247.
Kloppenburgh-Versteegh. 2006. Tanaman berkhasiat Indonesia. IPB Press, Bogor.
Lee SH, Li Y, Karadeniz F, Kim MM, and Kim SK. 2009. ?-Glucosidase and ?-amylase inhibitory activities of Phloroglucinal derivatives from edible marine brown alga, Ecklonia cava. J Sci Food Agric 89:1551–15558.
Mezit A, Meziti H, Boudiaf K, Mustapha B, Bouriche H. 2012. Polyphenolic profile and antioxidant activities of Nigella Sativa seed extracts in vitro and in vivo. World Acad Sci Eng Technol 64:24-32.
Mogea JP , Gandawidjaya D, Wriadinata H, Nasution RE, Irawati. 2001. Tumbuhan Langka Indonesia. Pusat Penelitian dan Pengembangan Biologi – LIPI, Bogor.
Noh H, Ha H. 2011. Reactive oxygen species and oxidative stress. Contrib Nephrol 170:102-112.
Pham-Huy LA, He H, Pham-Huy C. 2008. Free radicals, antioxidants in disease and health. Int J Biomed Sci 4(2):89–96.
Piao MJ, Kang KA, Zhang R, Ko DO, Wang ZH, Lee KH, Chang WY, Chae S, Jee Y, Shin T, Park JW, Lee NH, Hyun JW. 2009. Antioxidant Properties of 1,2,3,4,6-Penta-O-galloyl-?-D-glucose from Elaeocarpus sylvestris var. ellipticus. Food Chem 115:412–418.
Prihantini AI, Tachibana S, Itoh K. 2014. Evaluation of antioxidant and ?-glucosidase inhibitory activities of some subtropical plants. Pak J Biol Sci 17(10):1106-1114.
Rice-Eans CA, Miller NJ, Paganga G. Structure-antioxidant relationships of flavonoids and phenolic acids. Free radic boil med. 1996:20:933-56.
Ruberto, G, Baratta MT, Antioxidant activity of selected essential oil components in two lipid model system. Food chem. 2000:69:167-174.
Sancheti S, Sancheti S, Bafna M, Seo SY. 2011. 2,4,6-Trihydroxybenzaldehyde as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats. Med Chem Res 20:1181–1187.
Sari KAI, Gunawan IWG, Putra KGD. 2015. Kapasitas antioksidan senyawa golongan triterpenoid pada daun pranajiwa (Euchresta horsfieldii Lesch Benn). J Chem 9(1).
Shibano M, Kakutani K, Taniguchi M, Yasuda M, Baba K. 2008. Antioxidant constituent in the dayflower (Commelina communis L.) and their ?–glucosidase inhibitory activity. J Nat Med 62:349-353.
Singleton VL, Orthofer R, Raventos RML. 1999. Analysis of total phenols and other oxidation substrates and antioxidant by means of Folin-Ciocalteu reagent. Methods Enzymol 299:152–178.
Tirta IG, Ardaka IM, Darma IDP. 2010. Studi fenologi dan senyawa kimia pronojiwo (Euchresta horsfieldii (Lesch.) Benn.). BULLITRO, 21(1):28-36.
Van de Laar FA, Lucassen PLBJ, Akkermans RP, Van de Lisdonk EH, Rutten GEHM, Van Weel C. 2005. Alpha-glucosidase inhibitors for type 2 diabetes mellitus (review). Cochrane Database Syst Rev 28(1):154–163.