Association of thyroid disorders with diabetes: A cross-sectional study

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DOI https://doi.org/10.13057/nusbiosci/n140201
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Vol. 14 No. 2 (2022)
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Articles

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MUBASHIR ZAFAR
College of Public Health, Imam Abdul Rehman bin Faisal University. Dammam 34212, Kingdom of Saudi Arabia
SYED MONWAR ALAM SHAHID ♥
Department of Biochemistry, College of Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia
REEM FALAH ALSHAMMARI
Department of Family and Community Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia
MOHD ADNAN KAUSAR
Department of Biochemistry, College of Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia.
TARIG A. N. GINAWI
Department of Biochemistry, College of Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia.
ABDUL WAHAB HATIM
Department of Biochemistry, College of Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia.
ABDUL MAJEED WADI
Department of Biochemistry, College of Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia.
HAMAD ALI
Department of Biochemistry, College of Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia
ABDUL AZIZ HAMED
Department of Biochemistry, College of Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia
MOATH SALEH AL-ZAHRANI
Department of Biochemistry, College of Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia
ALI HUSSAIN
Department of Biochemistry, College of Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia
ABDULAZIZ SAUD ALDUHAIM
Department of Biochemistry, College of Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia
ABDULMAJEED MOHAMMED
Department of Biochemistry, College of Medicine, University of Hail. Hail 55476, Kingdom of Saudi Arabia.

Abstract

Abstract. Zafar M, Shahid SMA, Alshammari RF, Kausar MA, Ginawi TAN, Hatim AW, Wadi AM, Ali H, Hamed AA, Al-Zahrani MS, Hussain A, Alduhaim AS, Mohammed A. 2022. Association of thyroid disorders with diabetes: A cross-sectional study. Nusantara Bioscience 14: 135-140. Two common endocrine disorders that correlate with each other are diabetes mellitus (DM) and thyroid dysfunction (TD). Undiagnosed thyroid disorders (TD) have a high risk for diabetes mellitus (DM) patients. A common complication among these patients is cardiovascular disease. This study aims to assess the association of TD among diabetes patients. It is a cross-sectional study, and 338 patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) were observed through a simple random sampling method from a public sector hospital. The diabetes status of patients was confirmed through clinical and laboratory investigation. Those patients who were under treatment of thyroid were excluded from the study. The chi-square test was used for analysis, and a p-value <0.05 was considered significant. The frequency of TD among diabetic patients was 47.6%. The main type of TD was subclinical hypothyroidism, and its prevalence is 43.8% and 23.5% among patients with T1DM and T2DM, respectively. Subclinical hyperthyroidism prevalences are 12.3% and 24.4% among TIDM and T2DM patients, respectively. The study found a high-frequency rate of TD among DM patients. Therefore, there is a need for regular screening of DM patients for TD and increased awareness regarding TD among DM patients.

2019-01-01

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References
Al-Omrani A, Al-bahadily AK, Reyadh, E. 2018. Autoimmune thyroid disorder in children and adolescents with type I diabetes mellitus. Intl J Pediatr 6 (4): 7433-7442. DOI: 10.22038/IJP.2018.28918.2524.
Al-Rubaye HF. 2019. Thyroid dysfunction in patients with uncontrolled type 2 diabetes mellitus. Mustansiriya Med J 18 (1): 16. DOI: 10.4103/MJ.MJ_4_18.
Bano A, Chaker L, Mattace-Raso FU, Terzikhan N, Kavousi M, Ikram MA, Franco OH. 2019. Thyroid function and life expectancy with and without noncommunicable diseases: A population-based study. PLoS Med 16 (10): e1002957. DOI: 10.1371/journal.pmed.1002957.
Bellastella G, Maiorino MI, Scappaticcio L, Casciano O, Petrizzo M, Caputo M, Esposito K. 2018. TSH oscillations in young patients with type 1 diabetes may be due to glycemic variability. J Endocrinol Investig 41 (4): 389-393. DOI: 10.1007/s40618-017-0752-5.
Biondi B, Kahaly GJ, Robertson RP. 2019. Thyroid dysfunction and diabetes mellitus: Two closely associated disorders. Endocr Rev 40 (3): 789-824. DOI: 10.1210/er.2018-00163.
Chang CH, Yeh YC, Shih SR, Lin JW, Chuang LM, Caffrey JL, Tu YK. 2017. Association between thyroid dysfunction and dysglycaemia: A prospective cohort study. Diabet Med 34 (11): 1584-1590. DOI: 10.1111/dme.13420.
Chen RH, Chen HY, Man KM, Chen SJ, Chen W, Liu PL, Chen WC. 2019. Thyroid diseases increased the risk of type 2 diabetes mellitus: A nation-wide cohort study. Medicine 98 (20): e15631. DOI: 10.1097/MD.0000000000015631.
Chuang MH, Liao KM, Hung YM, Wang PYP, Chou YC, Chou P. 2016. Abnormal thyroidstimulating hormone and chronic kidney disease in elderly adults in Taipei City. J Am Geriatr Soc 64 (6): 1267-1273. DOI: 10.1111/jgs.14102.
de Vries TI, Kappelle LJ, van der Graaf Y, de Valk HW, de Borst GJ, Nathoe HM, Westerink J. 2019. Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus. Actadiabetologica 56 (4): 431-440. DOI: 10.1007/s00592-018-1231-y.
Evron JM, Esfandiari NH, Papaleontiou M. 2020. Cancer incidence and mortality following treatment of hyperthyroidism with radioactive iodine. Curr Opin Endocrinol Diabetes Obes 27 (5): 323. DOI: 10.1097/MED.0000000000000561.
Giugliano D, Bellastella G, Longo M, Scappaticcio L, Maiorino MI, Chiodini P, Esposito K. 2020. Relationship between improvement of glycaemic control and reduction of major cardiovascular events in 15 cardiovascular outcome trials: A meta?analysis with meta?regression. Diabetes Obes Metab 22 (8): 1397-1405. DOI: 10.1111/dom.14047.
Gronich N, Deftereos SN, Lavi I, Persidis AS, Abernethy DR, Rennert G. 2015. Hypothyroidism is a risk factor for new-onset diabetes: A cohort study. Diabetes Care 38 (9): 1657-1664. DOI: 10.2337/dc14-2515.
Groothof D, Flores-Guerrero JL, Nolte IM, Bouma HR, Gruppen EG, Bano A, Bakker SJ. 2021. Thyroid function and risk of all-cause and cardiovascular mortality: A prospective population-based cohort study. Endocrine 71 (2): 385-396. DOI: 10.1007/s12020-020-02397-z.
Gu Y, Li H, Bao X, Zhang Q, Liu L, Meng G, Niu K. 2017. The relationship between thyroid function and the prevalence of type 2 diabetes mellitus in euthyroid subjects. J Clin Endocrinol Metab 102 (2): 434-442. DOI:10.1210/jc.2016-2965.
Hall KS, Hyde ET, Bassett DR, Carlson SA, Carnethon MR, Ekelund U, Fulton JE. 2020. Systematic review of the prospective association of daily step counts with risk of mortality, cardiovascular disease, and dysglycemia. Intl J Behav Nutr Phys Act 17 (1): 1-14 DOI: 10.1186/s12966-020-00978-9.
Haryta FS, Listyawati S, Pangastuti A. 2021. The effect of perennial sow-thistle (Sonchus arvensis) leaf extract on blood glucose and plasma insulin levels of diabetic mice. Cell Biol Dev 5: 63-69. DOI: 10.13057/cellbioldev/t050202.
Hasan BF, Ibrahim NA, Abd DA. 2016. Estimation of thyroid hormones and liver enzymes levels in hypo and hyperthyroidism in Iraqi women. Intl J Pharm Biol Sci 7 (4): 707-713. DOI: 10.22376/ijpbs.2016.7.4.b707-713.
Hoermann R, Midgley JE, Larisch R, Dietrich JW. 2021. Treatment options for subclinical hypothyroidism. Eur J Endocrinol 185 (3): L5-L6. DOI: 10.1530/EJE-20-1405.
Hussain T, Barik BS, Nayak AR, Das S, Khadanga UK, Yadav VS, Pati S. 2019. Prevalence and predictors of thyroid dysfunction among patients with type 2 diabetes mellitus attending a tertiary care hospital in an urban area of Bhubaneswar, Odisha. Thyroid Res Pract 16 (1): 26. DOI: 10.4103/trp.trp_48_18.
Ittermann T, Schipf S, Dörr M, Thuesen BH, Jørgensen T, Völzke H, Markus MRP. 2018. Hyperthyroxinemia is positively associated with prevalent and incident type 2 diabetes mellitus in two population-based samples from Northeast Germany and Denmark. Nutr Metab Cardiovasc Dis 28 (2): 173-179. DOI: 10.1016/j.numecd.2017.10.016.
Journy NM, Bernier MO, Doody MM, Alexander BH, Linet MS, Kitahara CM. 2017. Hyperthyroidism, hypothyroidism, and cause-specific mortality in a large cohort of women. Thyroid 27 (8): 1001-1010. DOI:10.1089/thy.2017.0063.
Jun JE, Jee JH, Bae JC, Jin SM, Hur KY, Lee MK, Kim JH. 2017b. Association between changes in thyroid hormones and incident type 2 diabetes: A seven-year longitudinal study. Thyroid 27 (1): 29-38. DOI: 10.1089/thy.2016.0171.
Jun JE, Jin SM, Jee JH, Bae JC, Hur KY, Lee MK, Kim JH. 2017a. TSH increment and the risk of incident type 2 diabetes mellitus in euthyroid subjects. Endocrine 55 (3): 944-953. DOI: 10.1007/s12020-016-1221-1.
Kalra S, Aggarwal S, Khandelwal D. 2019. Thyroid dysfunction and type 2 diabetes mellitus: screening strategies and implications for management. Diabetes Ther 10 (6): 2035-2044. DOI:10.1007/s13300-019-00700-4.
Luna-Vazquez F, Cruz-Lumbreras R, Rodríguez-Castelán J, Cervantes-Rodríguez M, Rodríguez-Antolín J, Arroyo-Helguera O, Cuevas E. 2014. Association between the serum concentration of triiodothyronine with components of metabolic syndrome, cardiovascular risk, and diet in euthyroid post-menopausal women without and with metabolic syndrome. Springerplus 3 (1): 1-8. DOI: 10.1186/2193-1801-3-266.
Mehran L, Amouzegar A, Bakhtiyari M, Mansournia MA, Rahimabad PK, Tohidi M, Azizi F. 2017. Variations in serum free thyroxine concentration within the reference range predicts the incidence of metabolic syndrome in non-obese adults: A cohort study. Thyroid 27 (7): 886-893. DOI: 10.1089/thy.2016.0557.
Mehran L, Amouzegar A, Tohidi M, Moayedi M, Azizi F. 2014. Serum free thyroxine concentration is associated with metabolic syndrome in euthyroid subjects. Thyroid 24 (11): 1566-1574. DOI: 10.1089/thy.2014.0103.
Moleti M, Mauro MD, Alibrandi A, Vita R, Benvenga S, Vermiglio F. 2020. Postpartum thyroiditis in women with euthyroid and hypothyroid Hashimoto’s thyroiditis antedating pregnancy. J Clin Endocrinol Metab 105 (7): e2421-e2428. DOI: 10.1210/clinem/dgaa197.
Ogbonna SU, Ezeani IU, Okafor CI, Chinenye S. 2019. Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus. Diabetes, metabolic syndrome and obesity: Targets and therapy 12: 1113. DOI: 10.2147/DMSO.S204836.
Palma CCSV, Pavesi M, Nogueira VG, Clemente ELS, Vasconcellos MDFBMP, Pereira LC, Gomes MB. 2013. Prevalence of thyroid dysfunction in patients with diabetes mellitus. Diabetol Metab Syndr 5 (1): 1-5. DOI: 10.1186/1758-5996-5-58.
Ralli M, Angeletti D, Fiore M, D'Aguanno V, Lambiase A, Artico M, Greco A. 2020. Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation. Autoimmun Rev 19 (10): 102649. DOI: 10.1016/j.autrev.2020.102649.
Ryödi E, Metso S, Huhtala H, Välimäki M, Auvinen A, Jaatinen P. 2018. Cardiovascular morbidity and mortality after treatment of hyperthyroidism with either radioactive iodine or thyroidectomy. Thyroid 28 (9): 1111-1120. DOI: 10.1089/thy.2017.0461.
Sawin CT, Geller A, Wolf PA, Belanger AJ, Baker E, Bacharach P, Wilson P, Benjamin EJ, D'Agostino RB. 1994. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med 331: 1249-1252. DOI: 10.1056/NEJM199411103311901.
Sert UY, Buyuk GN, Ustun YE, Erdinc ASO. 2020. Is there any relationship between thyroid function abnormalities, thyroid antibodies and development of gestational diabetes mellitus (GDM) in pregnant women? Medeni Med J 35 (3): 195. DOI: 10.5222/MMJ.2020.29964.
Shahid SMA, Ginawi TA, Alshammari AWHM, Alshammiri AWM, Alduhaim AS, Alshammari AM, Alzahrani MS. 2020. Prevalence of thyroid dysfunction in the patients with diabetes mellitus and its risk factors in the population of Hail Region, Saudi Arabia: A cross-sectional study. World J Pharmac Res 10 (3): 1176-1185. DOI: 10.2147/DMSO.S204836.
Song F, Bao C, Deng M, Xu H, Fan M, Paillard-Borg S, Qi X. 2017. The prevalence and determinants of hypothyroidism in hospitalized patients with type 2 diabetes mellitus. Endocrine 55 (1) 179-185. DOI: 10.1007/s12020-016-1095-2.
Song RH, Wang B, Yao QM, Li Q, Jia X, Zhang JA. 2019. The impact of obesity on thyroid autoimmunity and dysfunction: A systematic review and meta-analysis. Front Immunol 10: 2349. DOI: 10.3389/fimmu.2019.02349.
Tang Y, Yan T, Wang G, Chen Y, Zhu Y, Jiang Z, Ni C. 2017. Correlation between insulin resistance and thyroid nodule in type 2 diabetes mellitus. Intl J Endocrinol 2017: 1617458. DOI: 10.1155/2017/1617458.
Zhang HM, Feng QW, Niu YX, Su Q, Wang X. 2019. Thyroid nodules in type 2 diabetes mellitus. Curr Med Sci 39 (4): 576-581. DOI: 10.1007/s11596-019-2076-5.
Zhao W, Zeng H, Zhang X, Liu F, Pan J, Zhao J, Jia W. 2016. A high thyroid stimulating hormone level is associated with diabetic peripheral neuropathy in type 2 diabetes patients. Diabetes Res Clin Pract 115: 122-129. DOI: 1016/j.diabres.2016.01.018.
Zhou PA, Zhang CH, Chen YR, Dong LI, Dai Yu, SONG, Liu HM, Chen SY. 2019. Association between metabolic syndrome and carotid atherosclerosis: A cross-sectional study in Northern China. Biomed Environ Sci 32 (12): 914-921. DOI: 10.2337/diacare.26.4.1251.