Determining the relevance of HLA/KIR matching/mismatching on kidney and liver transplantation rejection: A meta-analysis
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Abstract. Batuan B, Cajayon CJ, Castro BA, Austria ML, Co DN, Ebreo SK, Clemente B, Tiongco RE. 2021. Determining the relevance of HLA/KIR matching/mismatching on kidney and liver transplantation rejection: A meta-analysis. Nusantara Bioscience 13: 211-218. The kidney and liver are solid organs commonly transplanted nowadays. However, there are cases wherein graft rejection occurs due to foreign Human Leukocyte Antigen (HLA) proteins. Furthermore, the function of Natural Killer (NK) cells and their receptors in solid organ transplantation is not yet fully elucidated. This study aims to determine the relevance of matching HLA/Killer cell Immunoglobulin-like Receptors (KIR) with kidney and liver transplantation outcomes. First, articles were screened according to the inclusion and exclusion criteria provided, which garnered eight definitive studies. Next, data were tabulated using a standardized extraction form. A meta-analysis was conducted to formulate conclusions regarding the significance of HLA/KIR matching and mismatching in kidney and liver transplantations. Fixed- and random-effects models were utilized to compute and establish 95% CI and pooled ORs wherein a p-value of less than 0.05 is considered significant. A combined Chi-square-based Q test and I2 statistics were used to identify heterogeneity, which was resolved with a funnel plot. In this meta-analysis, only the HLA-Bw4/KIR3DL1 combination was found significant to lower the risk of allograft rejection (OR=0.73; PA=0.009; PH=0.42). Other combinations include HLA-C1 and KIR2DL2/3, HLA-C1 and KIR2DS2/3, HLA-C2 and KIR2DL1/DS2, and HLA-Bw4/KIR3DS1 were found to be insignificant; hence, these do not influence the allograft rejections. In conclusion, the role of HLA/KIR combinations on solid organ transplantation rejection is only significant in HLA-Bw4/KIR3DL1 interaction, which correlates with decreased odds of allograft rejection. Factors including KIR allele variations, insufficient data and journals related to the topic, and unestablished association of HLA/KIR in other organ transplantations affected the results of this meta-analysis; thus, these are recommended to be considered in future studies.
2019-01-01
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References
Alam, S., Rangaswamy, D., Prakash, S., Sharma, R., Khan, M., Sonawane, A., & Agrawal, S. (2015). Impact of killer immunoglobulin-like receptor-human leukocyte antigens ligand incompatibility among renal transplantation. Indian Journal of Nephrology, 25(1), 27–33. https://doi.org/10.4103/0971-4065.134655
Ayala García, M. A., González Yebra, B., López Flores, A. L., & Guaní Guerra, E. (2012). The Major Histocompatibility Complex in Transplantation. Journal of Transplantation, 2012, 1–7. https://doi.org/10.1155/2012/842141
Bari, R., Bell, T., Leung, W. H., Vong, Q. P., Chan, W. K., Das Gupta, N., Holladay, M., Rooney, B., & Leung, W. (2009). Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine245. Blood, 114(25), 5182–5190. https://doi.org/10.1182/blood-2009-07-231977
Bishara, A., Brautbar, C., Zamir, G., Eid, A., & Safadi, R. (2005). Impact of HLA-C and Bw epitopes disparity on liver transplantation outcome. Human Immunology, 66(11), 1099–1105. https://doi.org/10.1016/j.humimm.2005.10.016
Brochot, E., Desoutter, J., Presne, C., De Araujo, I., Flahaut, G., Castelain, S., Westeel, P. F., Choukroun, G., & Guillaume, N. (2016). The association between killer-cell immunoglobulin-like receptor (KIR) and KIR ligand genotypes and the likelihood of BK virus replication after kidney transplantation. Transplant International, 29(11), 1168–1175. https://doi.org/10.1111/tri.12820
Burian, A., Wang, K. L., Finton, K. A. K., Lee, N., Ishitani, A., Strong, R. K., & Geraghty, D. E. (2016). HLA-F and MHC-I open conformers bind natural killer cell ig-like receptor KIR3DS1. PLoS ONE, 11(9), 1–12. https://doi.org/10.1371/journal.pone.0163297
Carr, W. H., Rosen, D. B., Arase, H., Nixon, D. F., Michaelsson, J., & Lanier, L. L. (2007). Cutting Edge: KIR3DS1 , a Gene Implicated in Resistance to Progression to AIDS, Encodes a DAP12-Associated Receptor Expressed on NK Cells That Triggers NK Cell Activation . The Journal of Immunology, 178(2), 647–651. https://doi.org/10.4049/jimmunol.178.2.647
Chewning, J. H., Gudme, C. N., Hsu, K. C., Selvakumar, A., & Dupont, B. (2007). KIR2DS1-Positive NK Cells Mediate Alloresponse against the C2 HLA-KIR Ligand Group In Vitro. The Journal of Immunology, 179(2), 854–868. https://doi.org/10.4049/jimmunol.179.2.854
Gaafar, A., Sheereen, A., Almohareb, F., Eldali, A., Chaudhri, N., Mohamed, S. Y., Hanbali, A., Shaheen, M., Alfraih, F., El Fakih, R., Iqneibi, A., Youniss, R., Elhassan, T., Hashmi, S., Aljurf, M., & Alhussein, K. (2018). Prognostic role of KIR genes and HLA-C after hematopoietic stem cell transplantation in a patient cohort with acute myeloid leukemia from a consanguineous community. Bone Marrow Transplantation, 53(9), 1170–1179. https://doi.org/10.1038/s41409-018-0123-7
Hanvesakul, R., Spencer, N., Cook, M., Gunson, B., Hathaway, M., Brown, R., Nightingale, P., Cockwell, P., Hubscher, S. G., Adams, D. H., Moss, P., & Briggs, D. (2008). Donor HLA-C genotype has a profound impact on the clinical outcome following liver transplantation. American Journal of Transplantation, 8(9), 1931–1941. https://doi.org/10.1111/j.1600-6143.2008.02341.x
Hilton, H. G., Vago, L., Older Aguilar, A. M., Moesta, A. K., Graef, T., Abi-Rached, L., Norman, P. J., Guethlein, L. A., Fleischhauer, K., & Parham, P. (2012). Mutation at Positively Selected Positions in the Binding Site for HLA-C Shows That KIR2DL1 Is a More Refined but Less Adaptable NK Cell Receptor Than KIR2DL3. The Journal of Immunology, 189(3), 1418–1430. https://doi.org/10.4049/jimmunol.1100431
Jafari, D., Nafar, M., Yekaninejad, M. S., Abdolvahabi, R., Pezeshki, M. L., Razaghi, E., & Amirzargar, A. A. (2017). Investigation of killer immunoglobulin-like receptor (KIR) and HLA genotypes to predict the occurrence of acute allograft rejection after kidney transplantation. Iranian Journal of Allergy, Asthma and Immunology, 16(3), 245–255. https://doi.org/10.4172/2155-6121.C1.003
Janeway, C. A., Travers, P., Walport, M., & Shlomchik, M. J. (2001). The major histocompatibility complex and its functions. https://www.ncbi.nlm.nih.gov/books/NBK27156/
Khakoo, S. I., & Jamil, K. M. (2011). KIR/HLA interactions and pathogen immunity. Journal of Biomedicine and Biotechnology, 2011. https://doi.org/10.1155/2011/298348
Knorr, D. A., Bachanova, V., Verneris, M. R., & Miller, J. S. (2014). Clinical utility of natural killer cells in cancer therapy and transplantation. Seminars in Immunology, 26(2), 161–172. https://doi.org/10.1016/j.smim.2014.02.002
Kreijveld, E., Van Der Meer, A., Tijssen, H. J., Hilbrands, L. B., & Joosten, I. (2007). KIR gene and KIR ligand analysis to predict graft rejection after renal transplantation. Transplantation, 84(8), 1045–1051. https://doi.org/10.1097/01.tp.0000286097.11173.70
Kunert, K., Seiler, M., Mashreghi, M. F., Klippert, K., Schönemann, C., Neumann, K., Pratschke, J., Reinke, P., Volk, H. D., & Kotsch, K. (2007). KIR/HLA ligand incompatibility in kidney transplantation. Transplantation, 84(11), 1527–1533. https://doi.org/10.1097/01.tp.0000290681.41859.41
La Manna, G., Corsini, S., Iannelli, S., Cappuccilli, M. L., Comai, G., Iorio, M., Todeschini, P., Carretta, E., Scolari, M. P., Bontadini, A., & Stefoni, S. (2013). Influence of the immunogenetic KIR and HLA systems on long-term renal transplant outcome. Annals of Transplantation, 18(1), 611–621. https://doi.org/10.12659/AOT.889157
Lee, H., Park, K. H., Park, H. S., Ryu, J. H., Lim, J., Kim, Y., Na, G. H., Kim, D. G., & Oh, E. J. (2017). Human leukocyte antigen-C genotype and killer immunoglobulin-like receptor-ligand matching in Korean living donor liver transplantation. Annals of Laboratory Medicine, 37(1), 45–52. https://doi.org/10.3343/alm.2017.37.1.45
Legaz, I., López-Álvarez, M. R., Campillo, J. A., Moya-Quiles, M. R., Bolarín, J. M., De La Peña, J., Salgado, G., Gimeno, L., García-Alonso, A. M., Muro, M., Miras, M., Alonso, C., Álvarez-López, M. R., & Minguela, A. (2013). KIR gene mismatching and KIR/C ligands in liver transplantation: Consequences for short-term liver allograft injury. Transplantation, 95(8), 1037–1044. https://doi.org/10.1097/TP.0b013e318286486c
Littera, R., Piredda, G., Argiolas, D., Lai, S., Congeddu, E., Ragatzu, P., Melis, M., Carta, E., Michittu, M. B., Valentini, D., Cappai, L., Porcella, R., Alba, F., Serra, M., Loi, V., Maddi, R., Orrù, S., La Nasa, G., Caocci, G., … Carcassi, C. (2017). KIR and their HLA Class I ligands: Two more pieces towards completing the puzzle of chronic rejection and graft loss in kidney transplantation. PLoS ONE, 12(7), 1–19. https://doi.org/10.1371/journal.pone.0180831
Locatelli, F., Moretta, F., Brescia, L., & Merli, P. (2014). Natural killer cells in the treatment of high-risk acute leukaemia. Seminars in Immunology, 26(2), 173–179. https://doi.org/10.1016/j.smim.2014.02.004
Mansouri, M., Villard, J., Ramzi, M., Alavianmehr, A., & Farjadian, S. (2020). Impact of donor KIRs and recipient KIR/HLA class I combinations on GVHD in patients with acute leukemia after HLA-matched sibling HSCT. Human Immunology, 81(6), 285–292. https://doi.org/10.1016/j.humimm.2020.03.004
Mattsson, J., Ringdén, O., & Storb, R. (2008). Graft Failure after Allogeneic Hematopoietic Cell Transplantation. Biology of Blood and Marrow Transplantation, 14(1 SUPPL.), 165–170. https://doi.org/10.1016/j.bbmt.2007.10.025
Middleton, D., & Gonzelez, F. (2010). The extensive polymorphism of KIR genes. Immunology, 129(1), 8–19. https://doi.org/10.1111/j.1365-2567.2009.03208.x
Miller, J. S., Soignier, Y., Panoskaltsis-Mortari, A., McNearney, S. A., Yun, G. H., Fautsch, S. K., McKenna, D., Le, C., Defor, T. E., Burns, L. J., Orchard, P. J., Blazar, B. R., Wagner, J. E., Slungaard, A., Weisdorf, D. J., Okazaki, I. J., & McGlave, P. B. (2005). Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood, 105(8), 3051–3057. https://doi.org/10.1182/blood-2004-07-2974
Moesta, A. K., & Parham, P. (2012). Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3. Frontiers in Immunology, 3(NOV), 1–13. https://doi.org/10.3389/fimmu.2012.00336
Moradi, S., Stankovic, S., O’Connor, G. M., Pymm, P., MacLachlan, B. J., Faoro, C., Retière, C., Sullivan, L. C., Saunders, P. M., Widjaja, J., Cox-Livingstone, S., Rossjohn, J., Brooks, A. G., & Vivian, J. P. (2021). Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-22359-x
Moroso, V., Van Der Meer, A., Tilanus, H. W., Kazemier, G., Van Der Laan, L. J. W., Metselaar, H. J., Joosten, I., & Kwekkeboom, J. (2011). Donor and recipient HLA/KIR genotypes do not predict liver transplantation outcome. Transplant International, 24(9), 932–942. https://doi.org/10.1111/j.1432-2277.2011.01286.x
Moya-Quiles, M. R., Muro, M., Torío, A., Sánchez-Bueno, F., Miras, M., Marían, L., García-Alonso, A. M., Parrilla, P., Dausset, J., & Álvarez-López, M. R. (2003). Human leukocyte antigen-C in short- and long- term liver graft acceptance. Liver Transplantation, 9(3), 218–227. https://doi.org/10.1053/jlts.2003.50043
Nowak, I., Majorczyk, E., Wi?niewski, A., Pawlik, A., Magott-Procelewska, M., Passowicz-Muszy?ska, E., Malejczyk, J., P?oski, R., Giebel, S., Barcz, E., Zo?-Giebel, A., Malinowski, A., Tchórzewski, H., Chlebicki, A., ?uszczek, W., Kurpisz, M., Grybo?, M., Wilczy?ski, J., Wiland, P., … Ku?nierczyk, P. (2010). Does the kir2ds5 gene protect from some human diseases? PLoS ONE, 5(8), 8–13. https://doi.org/10.1371/journal.pone.0012381
Pabalan, N., Jarjanazi, H., & Steiner, T. (2014). Meta-analysis in microbiology. Indian Journal of Medical Microbiology, 32(3), 229–235. https://doi.org/10.4103/0255-0857.136547
Prakash, S., Sarangi, A. N., Alam, S., Sonawane, A., Sharma, R. K., & Agrawal, S. (2017). Putative role of KIR3DL1/3DS1 alleles and HLA-Bw4 ligands with end stage renal disease and long term renal allograft survival. Gene, 637, 219–229. https://doi.org/10.1016/j.gene.2017.09.033
Sim, M. J. W., Malaker, S. A., Khan, A., Stowell, J. M., Shabanowitz, J., Peterson, M. E., Rajagopalan, S., Hunt, D. F., Altmann, D. M., Long, E. O., & Boyton, R. J. (2017). Canonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-C. Frontiers in Immunology, 8(MAR), 1–16. https://doi.org/10.3389/fimmu.2017.00193
Tran, T. H., Unterrainer, C., Fiedler, G., Döhler, B., Scherer, S., Ruhenstroth, A., Adamek, M., Middleton, D., & Opelz, G. (2013). No impact of KIR-ligand mismatch on allograft outcome in HLA-compatible kidney transplantation. American Journal of Transplantation, 13(4), 1063–1068. https://doi.org/10.1111/ajt.12134
Tran, T. Hien, Mytilineos, J., Scherer, S., Laux, G., Middleton, D., & Opelz, G. (2005). Analysis of KIR ligand incompatibility in human renal transplantation. Transplantation, 80(8), 1121–1123. https://doi.org/10.1097/01.tp.0000179110.15304.90
Tuttolomondo, A., Di Raimondo, D., Pecoraro, R., Casuccio, A., Di Bona, D., Aiello, A., Accardi, G., Arnao, V., Clemente, G., Corte, V. Della, Maida, C., Simonetta, I., Caruso, C., Squatrito, R., & Pinto, A. (2019). HLA and killer cell immunoglobulin-like receptor (KIRs) genotyping in patients with acute ischemic stroke. Journal of Neuroinflammation, 16(1), 1–15. https://doi.org/10.1186/s12974-019-1469-5
Upadhyay, R. K. (2019). ISSN:XXXX-XXXX SJOSC, an open access journal Volume 2 · Issue 1 · 1000006 SF J Stem Cell SciFed Journal on Stem Cells Clinical Issues Related to Safe Procurement of Organ Transplan... 2(1).
Vampa, M. L., Norman, P. J., Burnapp, L., Vaughan, R. W., Sacks, S. H., & Wong, W. (2003). Natural killer-cell activity after human renal transplantation in relation to killer immunoglobulin-like receptors and human leukocyte antigen mismatch. Transplantation, 76(8), 1220–1228. https://doi.org/10.1097/01.TP.0000083896.91215.C7
Van Der Touw, W., & Bromberg, J. S. (2010). Natural killer cells and the immune response in solid organ transplantation. American Journal of Transplantation, 10(6), 1354–1358. https://doi.org/10.1111/j.1600-6143.2010.03086.x
VandenBussche, C. J., Mulrooney, T. J., Frazier, W. R., Dakshanamurthy, S., & Hurley, C. K. (2009). Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule. Genes and Immunity, 10(2), 162–173. https://doi.org/10.1038/gene.2008.91
Willemze, R., Rodrigues, C. A., Labopin, M., Sanz, G., Michel, G., Socié, G., Rio, B., Sirvent, A., Renaud, M., Madero, L., Mohty, M., Ferra, C., Garnier, F., Loiseau, P., Garcia, J., Lecchi, L., Kögler, G., Beguin, Y., Navarrete, C., … Rocha, V. (2009). KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia. Leukemia, 23(3), 492–500. https://doi.org/10.1038/leu.2008.365
Zhao, X. Y., Chang, Y. J., Zhao, X. S., Xu, L. P., Zhang, X. H., Liu, K. Y., Li, D., & Huang, X. J. (2015). Recipient expression of ligands for donor inhibitory KIRs enhances NK-cell function to control leukemic relapse after haploidentical transplantation. European Journal of Immunology, 45(8), 2396–2408. https://doi.org/10.1002/eji.201445057