Anti-mycobacterial activity of methanol plants extract to against Mycobacterium bovis and Mycobacterium smegmatis

Abstract

Syahputra G, Sari M, Kusharyoto W. 2016. Anti-mycobacterial activity of methanol plants extract to against Mycobacterium bovis and Mycobacterium smegmatis. Pros Sem Nas Masy Biodiv Indon 2: 182-187. The plant is an important source of new drug for the treatment of tuberculosis (TB). Indonesian natural products derived from medicinal plants are important sources of TB therapeutics. This study aimed to screen for anti-mycobacterial activity derived from plants extract, such as Azadirachta indica, Zingiber americans, Desmodium triquetum, Clerodendron serratum, Caesalpinia sappan, and Morus alba in against Mycobacterium bovis and Mycobacterium smegmatis by using a disc diffusion method. Mycobacterium smegmatis is the most sensitive bacteria in treatment to plants extract. The extract of D. triquetrum, C. serratum and C. sappan showed the anti-mycobacterial activity in tested bacteria. Variation of extract concentration showed that the methanol extract of D. triquetrum is the most potential as an anti-mycobacterial. Based on a phytochemical assay, the compounds in D. triquertum contained flavonoids and tannins. It was needed to isolate the active compounds as an anti-mycobacterium.